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STRs are explicitly permitted citywide under a low‑regulation approach, with no dedicated STR caps or complex rules; compliance is straightforward (standard town business license plus fire/building inspections and the 4.5% state lodging tax).
Local STR Agent
STR specialist · Medicine Park, OK
Medicine Park is a tiny historic resort town in Comanche County, Oklahoma, with a year-round population of just a few hundred residents. Tucked along Medicine Creek at the foot of the Wichita Mountains, it is known for its cobblestone buildings, walkable creekside setting, and reputation as one of the oldest resort communities in the state. The town serves as a quiet gateway to the Wichita Mountains and the lakes of southwestern Oklahoma, sitting about 15 miles northwest of Lawton and roughly 90 miles southwest of Oklahoma City.
The headline draw nearby is the Wichita Mountains Wildlife Refuge, a sprawling federal preserve of granite peaks, mixed-grass prairie, and clear streams. The refuge is home to free-roaming herds of American bison, Rocky Mountain elk, and Texas longhorn, along with established hiking trails, rock-climbing areas, and a scenic drive through the heart of the mountains. From Medicine Park, the main visitor center and trailheads are within about 15 to 20 minutes by car.
Just north of town, Lake Lawtonka offers a peaceful complement to the refuge, with fishing, kayaking, and shoreline camping set against the eastern edge of the mountains. The surrounding state-managed lands draw visitors for hiking and sunset watching, and the lake is roughly a 10-minute drive from the village center.
For a closer-to-home experience, Medicine Park's Bath Lake — a spring-fed swimming hole set right in the heart of the village — remains a defining feature of the town. A short walk from the main strip, its clear water and cobblestone banks reflect the resort heritage that has defined Medicine Park since the early 1900s.
To the south, Fort Sill anchors the broader region as one of the oldest active U.S. Army installations and a hub for military history, while also adding steady year-round demand to the area's lodging market.
For short-term-rental owners, Medicine Park offers a distinctive combination of small-town charm, a walkable historic core, and direct access to one of Oklahoma's most scenic natural areas. With limited traditional lodging, growing weekend and outdoor-tourism interest, and proximity to both the Wichita Mountains and Lawton, the village is well positioned as a memorable base for travelers exploring southwestern Oklahoma.